학술논문
Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
Document Type
article
Author
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Most human diseases are systems diseases, and systems biomarkers are better fitted for diagnostic, prognostic, and treatment monitoring purposes. To search for systems biomarker candidates, lactate dehydrogenase (LDH), a housekeeping protein expressed in all living cells, was investigated. To this end, we analyzed the serum LDH activities from 172,933 patients with 48 clinically defined diseases and 9528 healthy individuals. Based on the median values, we found that 46 out of 48 diseases, leading by acute myocardial infarction, had significantly increased (p 0.8) for hepatic encephalopathy and lung fibrosis.