학술논문
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
Document Type
article
Author
Alexander Teumer; Layal Chaker; Stefan Groeneweg; Yong Li; Celia Di Munno; Caterina Barbieri; Ulla T. Schultheiss; Michela Traglia; Tarunveer S. Ahluwalia; Masato Akiyama; Emil Vincent R. Appel; Dan E. Arking; Alice Arnold; Arne Astrup; Marian Beekman; John P. Beilby; Sofie Bekaert; Eric Boerwinkle; Suzanne J. Brown; Marc De Buyzere; Purdey J. Campbell; Graziano Ceresini; Charlotte Cerqueira; Francesco Cucca; Ian J. Deary; Joris Deelen; Kai-Uwe Eckardt; Arif B. Ekici; Johan G. Eriksson; Luigi Ferrrucci; Tom Fiers; Edoardo Fiorillo; Ian Ford; Caroline S. Fox; Christian Fuchsberger; Tessel E. Galesloot; Christian Gieger; Martin Gögele; Alessandro De Grandi; Niels Grarup; Karin Halina Greiser; Kadri Haljas; Torben Hansen; Sarah E. Harris; Diana van Heemst; Martin den Heijer; Andrew A. Hicks; Wouter den Hollander; Georg Homuth; Jennie Hui; M. Arfan Ikram; Till Ittermann; Richard A. Jensen; Jiaojiao Jing; J. Wouter Jukema; Eero Kajantie; Yoichiro Kamatani; Elisa Kasbohm; Jean-Marc Kaufman; Lambertus A. Kiemeney; Margreet Kloppenburg; Florian Kronenberg; Michiaki Kubo; Jari Lahti; Bruno Lapauw; Shuo Li; David C. M. Liewald; Lifelines Cohort Study; Ee Mun Lim; Allan Linneberg; Michela Marina; Deborah Mascalzoni; Koichi Matsuda; Daniel Medenwald; Christa Meisinger; Ingrid Meulenbelt; Tim De Meyer; Henriette E. Meyer zu Schwabedissen; Rafael Mikolajczyk; Matthijs Moed; Romana T. Netea-Maier; Ilja M. Nolte; Yukinori Okada; Mauro Pala; Cristian Pattaro; Oluf Pedersen; Astrid Petersmann; Eleonora Porcu; Iris Postmus; Peter P. Pramstaller; Bruce M. Psaty; Yolande F. M. Ramos; Rajesh Rawal; Paul Redmond; J. Brent Richards; Ernst R. Rietzschel; Fernando Rivadeneira; Greet Roef; Jerome I. Rotter; Cinzia F. Sala; David Schlessinger; Elizabeth Selvin; P. Eline Slagboom; Nicole Soranzo; Thorkild I. A. Sørensen; Timothy D. Spector; John M. Starr; David J. Stott; Youri Taes; Daniel Taliun; Toshiko Tanaka; Betina Thuesen; Daniel Tiller; Daniela Toniolo; Andre G. Uitterlinden; W. Edward Visser; John P. Walsh; Scott G. Wilson; Bruce H. R. Wolffenbuttel; Qiong Yang; Hou-Feng Zheng; Anne Cappola; Robin P. Peeters; Silvia Naitza; Henry Völzke; Serena Sanna; Anna Köttgen; Theo J. Visser; Marco Medici
Source
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.