학술논문
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
Document Type
article
Author
Li Ren Kong; Richard Weijie Ong; Tuan Zea Tan; Nur Afiqah Binte Mohamed Salleh; Matan Thangavelu; Jane Vin Chan; Lie Yong Judice Koh; Giridharan Periyasamy; Jieying Amelia Lau; Thi Bich Uyen Le; Lingzhi Wang; Miyoung Lee; Srinivasaraghavan Kannan; Chandra S. Verma; Chwee Ming Lim; Wee Joo Chng; David P. Lane; Ashok Venkitaraman; Huynh The Hung; Chit Fang Cheok; Boon Cher Goh
Source
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Codon 158 gain-of-function mutant p53 (158-mutp53) promotes tumourigenesis in lung cancer. Here, the authors show that 158-mutp53 render cancers sensitive to cisplatin and p53 acetylation agents through a mechanism where acetylated mutant p53 upregulates TRAIP and inhibits NF-ĸB signaling.