학술논문
Epidemiologic History and Genetic Diversity Origins of Chikungunya and Dengue Viruses, Paraguay
Document Type
article
Author
Tiago Gräf; Cynthia Vazquez; Marta Giovanetti; Fernanda de Bruycker-Nogueira; Vagner Fonseca; Ingra Morales Claro; Jaqueline Goes de Jesus; Andrea Gómez; Joilson Xavier; Marcos Cesar Lima de Mendonça; Shirley Villalba; Juan Torales; Maria Liz Gamarra; Julien Thézé; Ana Maria Bispo de Filippis; Vasco Azevedo; Tulio de Oliveira; Leticia Franco; Carlos F. Campelo de Albuquerque; Sandra Irala; Edward Charles Holmes; Jairo Andrés Méndez Rico; Luiz Carlos Junior Alcantara
Source
Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1393-1404 (2021)
Subject
Language
English
ISSN
1080-6040
1080-6059
51485354
1080-6059
51485354
Abstract
Paraguay has been severely affected by emergent Zika and chikungunya viruses, and dengue virus is endemic. To learn more about the origins of genetic diversity and epidemiologic history of these viruses in Paraguay, we deployed portable sequencing technologies to strengthen genomic surveillance and determine the evolutionary and epidemic history of arthropod-borne viruses (arboviruses). Samples stored at the Paraguay National Central Laboratory were sequenced and subjected to phylogenetic analysis. Among 33 virus genomes generated, we identified 2 genotypes of chikungunya and 2 serotypes of dengue virus that circulated in Paraguay during 2014–2018; the main source of these virus lineages was estimated to be Brazil. The evolutionary history inferred by our analyses precisely matched the available travel history of the patients. The genomic surveillance approach used was valuable for describing the epidemiologic history of arboviruses and can be used to determine the origins and evolution of future arbovirus outbreaks.