학술논문
Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation
Document Type
article
Author
Chrispin Chaguza; Madikay Senghore; Ebrima Bojang; Rebecca A. Gladstone; Stephanie W. Lo; Peggy-Estelle Tientcheu; Rowan E. Bancroft; Archibald Worwui; Ebenezer Foster-Nyarko; Fatima Ceesay; Catherine Okoi; Lesley McGee; Keith P. Klugman; Robert F. Breiman; Michael R. Barer; Richard A. Adegbola; Martin Antonio; Stephen D. Bentley; Brenda A. Kwambana-Adams
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleotide substitution rates and intra-host homologous recombination.