학술논문
Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old
Document Type
article
Author
Debora Melo van Lent; Sarah Egert; Steffen Wolfsgruber; Luca Kleineidam; Leonie Weinhold; Holger Wagner-Thelen; Birgit Stoffel-Wagner; Horst Bickel; Birgitt Wiese; Siegfried Weyerer; Michael Pentzek; Frank Jessen; Matthias Schmid; Wolfgang Maier; Martin Scherer; Steffi G. Riedel-Heller; Alfredo Ramirez; Michael Wagner
Source
Nutrients, Vol 15, Iss 61, p 61 (2022)
Subject
Language
English
ISSN
2072-6643
Abstract
Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%,