학술논문
Volumetric breast density and risk of advanced cancers after a negative screening episode: a cohort study
Document Type
article
Author
Source
Breast Cancer Research, Vol 20, Iss 1, Pp 1-7 (2018)
Subject
Language
English
ISSN
1465-542X
Abstract
Abstract Background We evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode. Methods A cohort of 16,752 women aged 49–54 years at their first screening mammography in the Florence screening programme was followed for breast cancer (BC) incidence until the second screening round. Volumetric BD was measured using fully automated software. The cumulative incidence of advanced cancer after a negative screening episode (including stage II or more severe cancer during the screening interval - on average 28 months - and at the subsequent round) was calculated separately for Volpara density grade (VDG) categories. Results BC incidence gradually increased with the increas in BD: 3.7‰, 5.1‰, 5.4‰ and 9.1‰ in the VDG categories 1–4, respectively (p trend