학술논문
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Document Type
article
Author
William J. Young; Najim Lahrouchi; Aaron Isaacs; ThuyVy Duong; Luisa Foco; Farah Ahmed; Jennifer A. Brody; Reem Salman; Raymond Noordam; Jan-Walter Benjamins; Jeffrey Haessler; Leo-Pekka Lyytikäinen; Linda Repetto; Maria Pina Concas; Marten E. van den Berg; Stefan Weiss; Antoine R. Baldassari; Traci M. Bartz; James P. Cook; Daniel S. Evans; Rebecca Freudling; Oliver Hines; Jonas L. Isaksen; Honghuang Lin; Hao Mei; Arden Moscati; Martina Müller-Nurasyid; Casia Nursyifa; Yong Qian; Anne Richmond; Carolina Roselli; Kathleen A. Ryan; Eduardo Tarazona-Santos; Sébastien Thériault; Stefan van Duijvenboden; Helen R. Warren; Jie Yao; Dania Raza; Stefanie Aeschbacher; Gustav Ahlberg; Alvaro Alonso; Laura Andreasen; Joshua C. Bis; Eric Boerwinkle; Archie Campbell; Eulalia Catamo; Massimiliano Cocca; Michael J. Cutler; Dawood Darbar; Alessandro De Grandi; Antonio De Luca; Jun Ding; Christina Ellervik; Patrick T. Ellinor; Stephan B. Felix; Philippe Froguel; Christian Fuchsberger; Martin Gögele; Claus Graff; Mariaelisa Graff; Xiuqing Guo; Torben Hansen; Susan R. Heckbert; Paul L. Huang; Heikki V. Huikuri; Nina Hutri-Kähönen; M. Arfan Ikram; Rebecca D. Jackson; Juhani Junttila; Maryam Kavousi; Jan A. Kors; Thiago P. Leal; Rozenn N. Lemaitre; Henry J. Lin; Lars Lind; Allan Linneberg; Simin Liu; Peter W. MacFarlane; Massimo Mangino; Thomas Meitinger; Massimo Mezzavilla; Pashupati P. Mishra; Rebecca N. Mitchell; Nina Mononen; May E. Montasser; Alanna C. Morrison; Matthias Nauck; Victor Nauffal; Pau Navarro; Kjell Nikus; Guillaume Pare; Kristen K. Patton; Giulia Pelliccione; Alan Pittman; David J. Porteous; Peter P. Pramstaller; Michael H. Preuss; Olli T. Raitakari; Alexander P. Reiner; Antonio Luiz P. Ribeiro; Kenneth M. Rice; Lorenz Risch; David Schlessinger; Ulrich Schotten; Claudia Schurmann; Xia Shen; M. Benjamin Shoemaker; Gianfranco Sinagra; Moritz F. Sinner; Elsayed Z. Soliman; Monika Stoll; Konstantin Strauch; Kirill Tarasov; Kent D. Taylor; Andrew Tinker; Stella Trompet; André Uitterlinden; Uwe Völker; Henry Völzke; Melanie Waldenberger; Lu-Chen Weng; Eric A. Whitsel; James G. Wilson; Christy L. Avery; David Conen; Adolfo Correa; Francesco Cucca; Marcus Dörr; Sina A. Gharib; Giorgia Girotto; Niels Grarup; Caroline Hayward; Yalda Jamshidi; Marjo-Riitta Järvelin; J. Wouter Jukema; Stefan Kääb; Mika Kähönen; Jørgen K. Kanters; Charles Kooperberg; Terho Lehtimäki; Maria Fernanda Lima-Costa; Yongmei Liu; Ruth J. F. Loos; Steven A. Lubitz; Dennis O. Mook-Kanamori; Andrew P. Morris; Jeffrey R. O’Connell; Morten Salling Olesen; Michele Orini; Sandosh Padmanabhan; Cristian Pattaro; Annette Peters; Bruce M. Psaty; Jerome I. Rotter; Bruno Stricker; Pim van der Harst; Cornelia M. van Duijn; Niek Verweij; James F. Wilson; Dan E. Arking; Julia Ramirez; Pier D. Lambiase; Nona Sotoodehnia; Borbala Mifsud; Christopher Newton-Cheh; Patricia B. Munroe
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease.