학술논문
In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets
Document Type
article
Author
Michela Carlet; Kerstin Völse; Jenny Vergalli; Martin Becker; Tobias Herold; Anja Arner; Daniela Senft; Vindi Jurinovic; Wen-Hsin Liu; Yuqiao Gao; Veronika Dill; Boris Fehse; Claudia D. Baldus; Lorenz Bastian; Lennart Lenk; Denis M. Schewe; Johannes W. Bagnoli; Binje Vick; Jan Philipp Schmid; Alexander Wilhelm; Rolf Marschalek; Philipp J. Jost; Cornelius Miething; Kristoffer Riecken; Marc Schmidt-Supprian; Vera Binder; Irmela Jeremias
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Preclinical molecular models are useful that mimic a patient´s response to targeted therapy. Here, the authors establish an in vivo inducible RNAi-mediated gene silencing system in patient-derived xenograft models of acute leukemia to identify individual vulnerabilities and therapeutic targets.