학술논문
PI3K-AKT-mTOR Pathway is Dominant over Androgen Receptor Signaling in Prostate Cancer Cells
Document Type
article
Author
Source
Cellular Oncology, Vol 32, Iss 1-2, Pp 11-27 (2010)
Subject
Language
English
ISSN
1570-5870
1875-8606
1875-8606
Abstract
Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of the most important pathways implicated in prostate cancer. Previous work has shown that there is crosstalk between these two pathways; however, there are conflicting findings and the molecular mechanisms are not clear. Here we studied the AR–PI3K pathway crosstalk in prostate cancer cells in vitro as well as in vivo.