학술논문
Neratinib protects pancreatic beta cells in diabetes
Document Type
article
Author
Amin Ardestani; Sijia Li; Karthika Annamalai; Blaz Lupse; Shirin Geravandi; Aleksandra Dobrowolski; Shan Yu; Siying Zhu; Tyler D. Baguley; Murali Surakattula; Janina Oetjen; Lena Hauberg-Lotte; Raquel Herranz; Sushil Awal; Delsi Altenhofen; Van Nguyen-Tran; Sean Joseph; Peter G. Schultz; Arnab K. Chatterjee; Nikki Rogers; Matthew S. Tremblay; Weijun Shen; Kathrin Maedler
Source
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Type 1 as well as type 2 diabetes are characterized by a loss of insulin-producing β-cells. Here the authors show that the FDA-approved drug neratinib has beneficial effects on β-cell survival, insulin secretion, and glycemic control in mouse models of diabetes.