학술논문
Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
Document Type
article
Author
Réka Spohn; Lejla Daruka; Viktória Lázár; Ana Martins; Fanni Vidovics; Gábor Grézal; Orsolya Méhi; Bálint Kintses; Mónika Számel; Pramod K. Jangir; Bálint Csörgő; Ádám Györkei; Zoltán Bódi; Anikó Faragó; László Bodai; Imre Földesi; Diána Kata; Gergely Maróti; Bernadett Pap; Roland Wirth; Balázs Papp; Csaba Pál
Source
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Antimicrobial peptides (AMPs) are emerging as drug candidates, but the risk of pathogen resistance is not well understood. Here, the authors investigate AMP resistance evolution in E. coli, finding physicochemical features that make AMPs less prone to resistance and no cross- or horizontally-acquired resistance.