학술논문
SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease
Document Type
article
Author
Source
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2091-2093 (2020)
Subject
Language
English
ISSN
22221751
2222-1751
2222-1751
Abstract
ABSTRACTWe studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.