학술논문
Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment
Document Type
article
Author
Nidhi S. Mundada; Julio C. Rojas; Lawren Vandevrede; Elisabeth H. Thijssen; Leonardo Iaccarino; Obiora C. Okoye; Ranjani Shankar; David N. Soleimani-Meigooni; Argentina L. Lago; Bruce L. Miller; Charlotte E. Teunissen; Hillary Heuer; Howie J. Rosen; Jeffrey L. Dage; William J. Jagust; Gil D. Rabinovici; Adam L. Boxer; Renaud La Joie
Source
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
1758-9193
Abstract
Abstract Background Plasma phosphorylated tau (p-tau) has emerged as a promising biomarker for Alzheimer’s disease (AD). Studies have reported strong associations between p-tau and tau-PET that are mainly driven by differences between amyloid-positive and amyloid-negative patients. However, the relationship between p-tau and tau-PET is less characterized within cognitively impaired patients with a biomarker-supported diagnosis of AD. We conducted a head-to-head comparison between plasma p-tau217 and tau-PET in patients at the clinical stage of AD and further assessed their relationships with demographic, clinical, and biomarker variables. Methods We retrospectively included 87 amyloid-positive patients diagnosed with MCI or dementia due to AD who underwent structural MRI, amyloid-PET (11C-PIB), tau-PET (18F-flortaucipir, FTP), and blood draw assessments within 1 year (age = 66 ± 10, 48% female). Amyloid-PET was quantified in Centiloids (CL) while cortical tau-PET binding was measured using standardized uptake value ratios (SUVRs) referenced against inferior cerebellar cortex. Plasma p-tau217 concentrations were measured using an electrochemiluminescence-based assay on the Meso Scale Discovery platform. MRI-derived cortical volume was quantified with FreeSurfer. Mini-Mental State Examination (MMSE) scores were available at baseline (n = 85) and follow-up visits (n = 28; 1.5 ± 0.7 years). Results Plasma p-tau217 and cortical FTP-SUVR were correlated (r = 0.61, p