학술논문
Polymorphism of prion protein gene (PRNP) in Nigerian sheep
Document Type
article
Author
Adeniyi C. Adeola; Semiu F. Bello; Abdussamad M. Abdussamad; Akanbi I. Mark; Oscar J. Sanke; Anyebe B. Onoja; Lotanna M. Nneji; Nasiru Abdullahi; Sunday C. Olaogun; Lawal D. Rogo; Godwin F. Mangbon; Shamsudeen L. Pedro; Manasseh P. Hiinan; Muhammad M. Mukhtar; Jebi Ibrahim; Hayatu Saidu; Philip M. Dawuda; Rukayya K. Bala; Hadiza L. Abdullahi; Adebowale E. Salako; Samia Kdidi; Mohamed Habib Yahyaoui; Ting-Ting Yin
Source
Prion, Vol 17, Iss 1, Pp 44-54 (2023)
Subject
Language
English
ISSN
19336896
1933-690X
1933-6896
1933-690X
1933-6896
Abstract
ABSTRACTPolymorphism of the prion protein gene (PRNP) gene determines an animal’s susceptibility to scrapie. Three polymorphisms at codons 136, 154, and 171 have been linked to classical scrapie susceptibility, although many variants of PRNP have been reported. However, no study has investigated scrapie susceptibility in Nigerian sheep from the drier agro-climate zones. In this study, we aimed to identify PRNP polymorphism in nucleotide sequences of 126 Nigerian sheep by comparing them with public available studies on scrapie-affected sheep. Further, we deployed Polyphen-2, PROVEAN, and AMYCO analyses to determine the structure changes produced by the non-synonymous SNPs. Nineteen (19) SNPs were found in Nigerian sheep with 14 being non-synonymous. Interestingly, one novel SNP (T718C) was identified. There was a significant difference (P