학술논문
An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.