학술논문
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
Document Type
article
Author
Jana K. Sonner; Melanie Keil; Maren Falk-Paulsen; Neha Mishra; Ateequr Rehman; Magdalena Kramer; Katrin Deumelandt; Julian Röwe; Khwab Sanghvi; Lara Wolf; Anna von Landenberg; Hendrik Wolff; Richa Bharti; Iris Oezen; Tobias V. Lanz; Florian Wanke; Yilang Tang; Ines Brandao; Soumya R. Mohapatra; Lisa Epping; Alexandra Grill; Ralph Röth; Beate Niesler; Sven G. Meuth; Christiane A. Opitz; Jürgen G. Okun; Christoph Reinhardt; Florian C. Kurschus; Wolfgang Wick; Helge B. Bode; Philip Rosenstiel; Michael Platten
Source
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Food intake shapes intestinal microbiome composition, which in turn shapes adaptive immune responses. Here the authors show that dietary tryptophan restriction (DTR) protects mice from subsequent autoimmune neuropathology challenge by altering intestinal microbiota, highlighting the potential of diet-regulated microbiota to prevent immune pathology.