학술논문
COVIDTrach: a prospective cohort study of mechanically ventilated patients with COVID-19 undergoing tracheostomy in the UK
Document Type
article
Author
A Thompson; S Wilkinson; N Kumar; G Wong; J Smith; F Franco; P Smith; A Wilson; S Ghosh; S Shepherd; A Kumar; R Brown; D Williams; M Griffiths; J Sen; M Roberts; A McGrath; D Kumar; A Walker; A Gupta; N Sharma; P Shah; M Kumar; H Jones; P Paul; I Gonzalez; A Shah; V Srinivasan; M Kelly; P Surda; K Valchanov; S Saha; R Bentley; C Hall; J Ng; C Pearce; R Harris; H Wilson; N Amin; J Phillips; D Park; C Jennings; L Wren; B McGrath; D Walker; J Ahmed; S Menon; N Jain; R Mistry; E Jackson; W Rutherford; E France; S Mahalingam; C Hogan; A Burns; T Exall; J Rodrigues; C Xie; M Rouhani; E Paramasivam; A WILLIAMSON; K STEELE; D Dawson; S Linton; M Cameron; S Biswas; S Hodges; J Collier; J Collins; S Bennett; T Ali; N Bhatti; S Suresh; J Williamson; G Ambler; C Cook; D Baker; J Bates; J Blair; P Mukherjee; A Howard; B Cosway; M Anwar; S Fang; S Meghji; H Griffiths; M Keil; F GREEN; K Hussain; A Schache; C Lockie; S Winter; J Westwood; A Hormis; P Ward; C Walker; G Sandhu; T Davies; A Lloyd; L Linhartova; C SPENCER; A Courtney; L Bates; T Martín; T Tatla; L Ritchie; P Gill; S Shannon; A Arora; R Pinto; H Turner; J Whittaker; E Warner; L Leach; A Menon; J Higginson; G Warner; A Balfour; F Cooper; A Li; S Berry; R Gohil; M Celinski; J McEwan; E Riley; S Webster; I Ahmad; M Idle; K Jolly; S Burrows; S Parmar; B Morris; A Arya; S Mustafa; E Tam; D Chakravarty; M De; A Daudia; B Tehan; R Temple; J Broad; P Andrews; D Pennell; C Smart; R D’Souza; P Praveen; DJ Lin; M Osborne; A Coombs; T Hunt; M Singer; C Smyth; R Saha; G Walton; P Bishop; U Sheikh; R O'Brien; R Bhandari; A Rovira; S Sanyal; E Yeung; A Tse; N Lawrence; P Stimpson; H Saeed; K Fan; M Ashcroft; T Jacob; J Hadley; K Goodwin; Z Abdi; D Nair; B Hill; D Whitmore; N Macartney; P Sykes; N Mercer; R Sykes; S Siddiq; Nick JI Hamilton; AGM Schilder; MM George; GM Jama; J Goulder; C Schilling; S Laha; MA Birchall; NS Tolley; P Nankivell; O Breik; P Pracy; J Osher; C Huppa; P Stenhouse; F Ryba; EK Bhargava; D Ranford; A Takhar; C Tornari; M Verkerk; C Al-Yaghchi; M Jaafar; N Cereceda-Monteoliva; A Holroyd; K Ghufoor; H O'Mahony; H Drewery; A Mulcahy; T Magos; I Balasundaram; M Heliotis; A Loizidou; D York; R Exley; KA Solanki; P Kirticumar; A Shirazian; Y Bhatt; R Natt; N Banga; K Dhadwal; I Ekpemi; R Roplekar-Bance; N Glibbery; K Karamali; T Munroe-Gray; P Sethukumar; R Vasanthan; H Lee-Six; B Misztal; S Millington; M Musalia; A Cardozo; M Dunbobbin; S Shahidi; M Chachlani; J Fussey; M Misurati; S Ashok; H Aboulgheit; S Khwaja; R Anmolsingh; B Al-Dulaimy; E Omakobia; T Browning; L Lignos; P Twose; J Heyman; D Kathwadia; T Hwara; O Judd; W Parker; TP Davis; T Stubington; H Koumoullis; E Willcocks; L Skelly; G Dempsey; K Liatsikos; B Borgatta; A Glossop; V Politidis; D Dhariwal; A Kara; G Tattersall; W Udall; P Kirkland; J Staufenberg; H Buglass; NW Wahid; A Amlani; P Deutsch; K Markham; O Barker; A Easthope; S Glaze; D Bondin; D Thorley; K Kapoor; S Sirajuddin; F van Damme; O Mattoo; E Kershaw; S Dewhurst; S Blakeley; C Chivers; L Lindsey; R Glore; H Cunniffe; D Moult; D Zolger; J Bakmanidis; S Kandiah; A Pericleous; R Sheikh; U Nagalotimath; E El-Tabal; S Ghaffar; M Dallison; E Leakey; O Sanders; A Gomati; L Moir; CB Groba; C Davies-Husband; N Seymour; R Lovett; J Lunn; A Armson; K Hilliard; S Ladan; P Tsirevelou; V Ratnam; A Muddaiah; J Coakes; R Borg; A Tsagkovits; O Mulla; N Stobbs; D Pratap; Z Ghani; J Rocke; S Snape; A Hassaan; S Beckett; R Siau; C Lamont; C Blore; D Zakai; R Moorthy; P Bothma; A Syndercombe; N Keates; M Junaid; T Antonio; A Vijendren; V Venkatachalam; M Lechner; D Chandrasekharan; J Whiteside; S Dennis; A Eldahshan; H Paw; M Colomo-Gonzalez; N Mani; B Ranganathan; N Amiruddin; A Sladkowski; AK Abou-Foul; S Kishwan; P Naredla; A Al-Ajami; S Okhovat; E Carey; N Vallabh; A. Alatsatianos; R Townsley
Source
BMJ Surgery, Interventions, & Health Technologies, Vol 3, Iss 1 (2021)
Subject
Language
English
ISSN
2631-4940
Abstract
Objectives COVIDTrach is a UK multicentre prospective cohort study project that aims to evaluate the outcomes of tracheostomy in patients with COVID-19 receiving mechanical ventilation and record the incidence of SARS-CoV-2 infection among healthcare workers involved in the procedure.Design Data on patient demographic, clinical history and outcomes were entered prospectively and updated over time via an online database (REDCap). Clinical variables were compared with outcomes, with logistic regression used to develop a model for mortality. Participants recorded whether any operators tested positive for SARS-CoV-2 within 2 weeks of the procedure.Setting UK National Health Service departments involved in treating patients with COVID-19 receiving mechanical ventilation.Participants The cohort comprised 1605 tracheostomy cases from 126 UK hospitals collected between 6 April and 26 August 2020.Main outcome measures Mortality following tracheostomy, successful wean from mechanical ventilation and length of time from tracheostomy to wean, discharge from hospital, complications from tracheostomy, reported SARS-CoV-2 infection among operators.Results The median time from intubation to tracheostomy was 15 days (IQR 11, 21). 285 (18%) patients died following the procedure. 1229 (93%) of the survivors had been successfully weaned from mechanical ventilation at censoring and 1049 (81%) had been discharged from hospital. Age, inspired oxygen concentration, positive end-expiratory pressure setting, fever, number of days of ventilation before tracheostomy, C reactive protein and the use of anticoagulation and inotropic support independently predicted mortality. Six reports were received of operators testing positive for SARS-CoV-2 within 2 weeks of the procedure.Conclusions Tracheostomy appears to be safe in mechanically ventilated patients with COVID-19 and to operators performing the procedure and we identified clinical parameters that are predictive of mortality.Trial registration number The study is registered with ClinicalTrials.Gov (NCT04572438).