학술논문
A simple staging system using biomarkers for wild‐type transthyretin amyloid cardiomyopathy in Japan
Document Type
article
Author
Naoya Nakashima; Seiji Takashio; Mami Morioka; Masato Nishi; Toshihiro Yamada; Kyoko Hirakawa; Masanobu Ishii; Noriaki Tabata; Kenshi Yamanaga; Koichiro Fujisue; Daisuke Sueta; Hisanori Kanazawa; Tadashi Hoshiyama; Shinsuke Hanatani; Satoshi Araki; Hiroki Usuku; Eiichiro Yamamoto; Mitsuharu Ueda; Kenichi Matsushita; Kenichi Tsujita
Source
ESC Heart Failure, Vol 9, Iss 3, Pp 1731-1739 (2022)
Subject
Language
English
ISSN
2055-5822
Abstract
Abstract Aims It has been reported that a staging system combining N‐terminal pro‐B‐type natriuretic peptide and high‐sensitivity troponin T (hs‐cTnT) or estimated glomerular filtration rate (eGFR) is useful in patients with wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM). However, these studies were mainly conducted in Western countries, and their usefulness for the Japanese population is unclear. We examined and validated the staging system using hs‐cTnT, eGFR, and B‐type natriuretic peptide (BNP) in Japanese patients with ATTRwt‐CM. Methods and results We retrospectively evaluated 176 patients with ATTRwt‐CM. The cut‐off values of hs‐cTnT and eGFR were selected as 0.05 ng/mL and 45 mL/min/1.73 m2, respectively, based on a previous report. The optimal cut‐off value of BNP was 255.6 pg/mL to predict all‐cause mortality (sensitivity, 75%; specificity, 58%; area under the curve, 0.69; 95% confidence interval [CI], 0.61–0.78; P 0.05 ng/mL) and BNP (>250 pg/mL) and decreased eGFR (