학술논문
Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Around half of the heritability underpinning familial high-grade serous ovarian carcinoma remains unidentified. Here, the authors show that extremely rare protein encoding loss-of-function variants, with a high degree of genetic heterogeneity, may account for some of this missing heritability.