학술논문
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ
Document Type
article
Author
Lina Ding; Ying Su; Anne Fassl; Kunihiko Hinohara; Xintao Qiu; Nicholas W. Harper; Sung Jin Huh; Noga Bloushtain-Qimron; Bojana Jovanović; Muhammad Ekram; Xiaoyuan Zi; William C. Hines; Maša Alečković; Carlos Gil del Alcazar; Ryan J. Caulfield; Dennis M. Bonal; Quang-De Nguyen; Vanessa F. Merino; Sibgat Choudhury; Gabrielle Ethington; Laura Panos; Michael Grant; William Herlihy; Alfred Au; Gedge D. Rosson; Pedram Argani; Andrea L. Richardson; Deborah Dillon; D. Craig Allred; Kirsten Babski; Elizabeth Min Hui Kim; Charles H. McDonnell; Jon Wagner; Ron Rowberry; Kristie Bobolis; Celina G. Kleer; E. Shelley Hwang; Joanne L. Blum; Simona Cristea; Piotr Sicinski; Rong Fan; Henry W. Long; Saraswati Sukumar; So Yeon Park; Judy E. Garber; Mina Bissell; Jun Yao; Kornelia Polyak
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Myoepithelial cells prevent tumour growth and invasion in DCIS. Here, the authors show that p63 and TCF7 cooperate to regulate a transcription factor network for the maintenance of normal myoepithelial function and altered expression of these genes perturb myoepithelial function in DCIS to promote invasive progression.