학술논문
Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls
Document Type
article
Author
Fanny Senner; Thomas Schneider-Axmann; Lalit Kaurani; Jörg Zimmermann; Jens Wiltfang; Martin von Hagen; Thomas Vogl; Carsten Spitzer; Simon Senner; Eva C. Schulte; Max Schmauß; Sabrina K. Schaupp; Jens Reimer; Daniela Reich-Erkelenz; Sergi Papiol; Mojtaba Oraki Kohshour; Fabian U. Lang; Carsten Konrad; Sophie-Kathrin Kirchner; Janos L. Kalman; Georg Juckel; Maria Heilbronner; Urs Heilbronner; Christian Figge; Ruth E. Eyl; Detlef Dietrich; Monika Budde; Ion-George Angelescu; Kristina Adorjan; Andrea Schmitt; Andre Fischer; Peter Falkai; Thomas G. Schulze
Source
Schizophrenia Research: Cognition, Vol 32, Iss , Pp 100280- (2023)
Subject
Language
English
ISSN
2215-0013
Abstract
As core symptoms of schizophrenia, cognitive deficits contribute substantially to poor outcomes. Early life stress (ELS) can negatively affect cognition in patients with schizophrenia and healthy controls, but the exact nature of the mediating factors is unclear. Therefore, we investigated how ELS, education, and symptom burden are related to cognitive performance.The sample comprised 215 patients with schizophrenia (age, 42.9 ± 12.0 years; 66.0 % male) and 197 healthy controls (age, 38.5 ± 16.4 years; 39.3 % male) from the PsyCourse Study. ELS was assessed with the Childhood Trauma Screener (CTS). We used analyses of covariance and correlation analyses to investigate the association of total ELS load and ELS subtypes with cognitive performance.ELS was reported by 52.1 % of patients and 24.9 % of controls. Independent of ELS, cognitive performance on neuropsychological tests was lower in patients than controls (p