학술논문
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction
Document Type
article
Author
D. Julia Trembinski; Diewertje I. Bink; Kosta Theodorou; Janina Sommer; Ariane Fischer; Anke van Bergen; Chao-Chung Kuo; Ivan G. Costa; Christoph Schürmann; Matthias S. Leisegang; Ralf P. Brandes; Tijna Alekseeva; Boris Brill; Astrid Wietelmann; Christopher N. Johnson; Alexander Spring-Connell; Manuel Kaulich; Stanislas Werfel; Stefan Engelhardt; Marc N. Hirt; Kaja Yorgan; Thomas Eschenhagen; Luisa Kirchhof; Patrick Hofmann; Nicolas Jaé; Ilka Wittig; Nazha Hamdani; Corinne Bischof; Jaya Krishnan; Riekelt H. Houtkooper; Stefanie Dimmeler; Reinier A. Boon
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Aging induces cardiovascular disease, but which RNA molecules control cardiac aging is poorly understood. Here the authors identified the aging-regulated non-coding RNA Sarrah, which controls cardiomyocyte survival and cardiac function by inducing cardioprotective genes.