학술논문
MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion—study protocol for a randomized clinical trial
Document Type
article
Author
Kilian M. Treurniet; Natalie E. LeCouffe; Manon Kappelhof; Bart J. Emmer; Adriaan C. G. M. van Es; Jelis Boiten; Geert J. Lycklama; Koos Keizer; Lonneke S. F. Yo; Hester F. Lingsma; Wim H. van Zwam; Inger de Ridder; Robert J. van Oostenbrugge; Aad van der Lugt; Diederik W. J. Dippel; Jonathan M. Coutinho; Yvo B. W. E. M. Roos; Charles B. L. M. Majoie; for the MR CLEAN-NO IV Investigators
Source
Trials, Vol 22, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
1745-6215
Abstract
Abstract Background Endovascular treatment (EVT) has greatly improved the prognosis of acute ischemic stroke (AIS) patients with a proximal intracranial large vessel occlusion (LVO) of the anterior circulation. Currently, there is clinical equipoise concerning the added benefit of intravenous alteplase administration (IVT) prior to EVT. The aim of this study is to assess the efficacy and safety of omitting IVT before EVT in patients with AIS caused by an anterior circulation LVO. Methods MR CLEAN-NO IV is a multicenter randomized open-label clinical trial with blinded outcome assessment (PROBE design). Patients ≥ 18 years of age with a pre-stroke mRS