학술논문
Clinical feasibility of a label-free SERS assay for therapeutic drug monitoring of methotrexate
Document Type
article
Author
Source
Sensing and Bio-Sensing Research, Vol 44, Iss , Pp 100649- (2024)
Subject
Language
English
ISSN
2214-1804
Abstract
We present a therapeutic drug monitoring (TDM) feasibility study using a label-free surface-enhanced Raman spectroscopy (SERS)-based assay for quantifying methotrexate (MTX) from samples collected from children with acute lymphoblastic leukemia undergoing high-dose MTX therapy. We show that, when combined with an appropriate sample preparation (solid phase extraction) and multivariate data analysis (partial least squares regression), the SERS assay demonstrated a good correlation with a reference chromatographic method (r = 0.889, p