학술논문
Single cell derived mRNA signals across human kidney tumors
Document Type
article
Author
Matthew D. Young; Thomas J. Mitchell; Lars Custers; Thanasis Margaritis; Francisco Morales-Rodriguez; Kwasi Kwakwa; Eleonora Khabirova; Gerda Kildisiute; Thomas R. W. Oliver; Ronald R. de Krijger; Marry M. van den Heuvel-Eibrink; Federico Comitani; Alice Piapi; Eva Bugallo-Blanco; Christine Thevanesan; Christina Burke; Elena Prigmore; Kirsty Ambridge; Kenny Roberts; Felipe A. Vieira Braga; Tim H. H. Coorens; Ignacio Del Valle; Anna Wilbrey-Clark; Lira Mamanova; Grant D. Stewart; Vincent J. Gnanapragasam; Dyanne Rampling; Neil Sebire; Nicholas Coleman; Liz Hook; Anne Warren; Muzlifah Haniffa; Marcel Kool; Stefan M. Pfister; John C. Achermann; Xiaoling He; Roger A. Barker; Adam Shlien; Omer A. Bayraktar; Sarah A. Teichmann; Frank C. Holstege; Kerstin B. Meyer; Jarno Drost; Karin Straathof; Sam Behjati
Source
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.