학술논문
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
Document Type
article
Author
Aartik Sarma; Stephanie A. Christenson; Ashley Byrne; Eran Mick; Angela Oliveira Pisco; Catherine DeVoe; Thomas Deiss; Rajani Ghale; Beth Shoshana Zha; Alexandra Tsitsiklis; Alejandra Jauregui; Farzad Moazed; Angela M. Detweiler; Natasha Spottiswoode; Pratik Sinha; Norma Neff; Michelle Tan; Paula Hayakawa Serpa; Andrew Willmore; K. Mark Ansel; Jennifer G. Wilson; Aleksandra Leligdowicz; Emily R. Siegel; Marina Sirota; Joseph L. DeRisi; Michael A. Matthay; COMET Consortium; Carolyn M. Hendrickson; Kirsten N. Kangelaris; Matthew F. Krummel; Prescott G. Woodruff; David J. Erle; Carolyn S. Calfee; Charles R. Langelier
Source
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.