학술논문
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
Document Type
article
Author
Chuan Hong; Noel J. Byrne; Beata Zamlynny; Srivanya Tummala; Li Xiao; Jennifer M. Shipman; Andrea T. Partridge; Christina Minnick; Michael J. Breslin; Michael T. Rudd; Shawn J. Stachel; Vanessa L. Rada; Jeffrey C. Kern; Kira A. Armacost; Scott A. Hollingsworth; Julie A. O’Brien; Dawn L. Hall; Terrence P. McDonald; Corey Strickland; Alexei Brooun; Stephen M. Soisson; Kaspar Hollenstein
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Agonists of the orexin receptor 2 (OX2R) show promise in the treatment of narcolepsy. Cryo-EM structures of active-state OX2R bound to an endogenous peptide agonist and a small-molecule agonist suggest a molecular mechanism that rationalizes both receptor activation and inhibition.