부산대학교 도서관

Mariko Jitsumori,1,* Shinya Matsuzaki,1,* Masayuki Endo,1 Takeya Hara,1 Takuji Tomimatsu,1 Satoko Matsuzaki,2 Tatsuya Miyake,1 Tsuyoshi Takiuchi,1 Aiko Kakigano,1 Kazuya Mimura,1 Eiji Kobayashi,1 Yutaka Ueda,1 Tadashi Kimura1 1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan; 2Department of Obstetrics and Gynecology, Otemae Hospital, Osaka, Japan*These authors contributed equally to this workCorrespondence: Shinya Matsuzaki; Aiko KakiganoDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanTel +81-6-6879-3355Fax +81-6-6879-3359Email zacky@gyne.med.osaka-u.ac.jp; ai-kaki@gyne.med.osaka-u.ac.jpBackground: Uterine artery embolization (UAE) is used to treat severe postpartum hemorrhage (PPH). According to a few studies, UAE for PPH was associated with preterm birth, fetal growth restriction (FGR), and placenta accreta spectrum (PAS) in subsequent pregnancies. These previous studies, however, lacked controls, and to the best of our knowledge, no systematic literature reviews have been conducted thus far. We report the results of our retrospective case–control study of pregnancies after UAE at a single center and include a literature review to evaluate the risk of PAS in pregnancies after UAE.Methods: We retrospectively reviewed data from deliveries at our hospital between January 2012 and October 2017. We divided the delivery data into cases with previous UAEs performed for PPH (the post-UAE group) and those without UAEs (the non-UAE group, which included women without previous PPH). We defined PAS as cases in which hysterectomy was performed and pathological examination confirmed the diagnosis. Results are presented as odds ratios (ORs) with 95% confidence intervals (95% CIs).Results: We used data from 3155 patients in this study, of whom 16 patients had undergone UAE (post-UAE group) and 3139 had not (non-UAE group). We found no differences between the groups in terms of frequency of preterm births (12.5% versus 14.2%, respectively; OR, 0.863; 95% CI, 0.218 to 3.414; P = 0.84) or FGR (6.2% versus 10.0%, respectively; OR, 0.602; 95% CI, 0.104 to 3.584; P = 0.61). However, cases of PAS were significantly more common in the post-UAE group (37.5%) than in the non-UAE group (1.2%; OR, 50.303; 95% CI, 17.38 to 145.592; P < 0.01).Conclusion: Our results suggest that previous UAE is a significant risk factor for PAS.Keywords: placenta accreta, placenta accreta spectrum, uterine artery embolization, postpartum hemorrhage, obstetric outcomes