학술논문
mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
Document Type
article
Author
Zhengping Huang; Xiaomeng You; Liang Chen; Yan Du; Kailey Brodeur; Hyuk Jee; Qiang Wang; Grace Linder; Roxane Darbousset; Pierre Cunin; Margaret H. Chang; Alexandra Wactor; Brian M. Wauford; Marc J. C. Todd; Kevin Wei; Ying Li; Anais Levescot; Yoichiro Iwakura; Virginia Pascual; Nicole E. Baldwin; Pierre Quartier; Tianwang Li; Maria T. Gianatasio; Robert P. Hasserjian; Lauren A. Henderson; David B. Sykes; Elizabeth D. Mellins; Scott W. Canna; Julia F. Charles; Peter A. Nigrovic; Pui Y. Lee
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome. Here the authors implicate the mechanistic target of rapamycin complex 1 in murine models of Still’s disease and macrophage activation syndrome, and provide associations with clinical cases in patients