학술논문
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex
Document Type
article
Author
Rebecca G. Smith; Ehsan Pishva; Gemma Shireby; Adam R. Smith; Janou A. Y. Roubroeks; Eilis Hannon; Gregory Wheildon; Diego Mastroeni; Gilles Gasparoni; Matthias Riemenschneider; Armin Giese; Andrew J. Sharp; Leonard Schalkwyk; Vahram Haroutunian; Wolfgang Viechtbauer; Daniel L. A. van den Hove; Michael Weedon; Danielle Brokaw; Paul T. Francis; Alan J. Thomas; Seth Love; Kevin Morgan; Jörn Walter; Paul D. Coleman; David A. Bennett; Philip L. De Jager; Jonathan Mill; Katie Lunnon
Source
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Although epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, previous studies have been limited in sample size and brain region used. Here, the authors combine data from six DNA methylomic studies of Alzheimer’s disease (N = 1453 unique individuals) to identify differentially methylated loci across cortex.