학술논문
Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
Document Type
article
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Chronic use of mTORC1 inhibitors produces undesirable side effects in humans which limit their value for CNS disorders treatment. The authors present a binary drug strategy to protects mTORC1 activity in the periphery and show its potential utility in preclinical models of alcohol use disorder.