학술논문
The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice
Document Type
article
Author
Yuka Inaba; Emi Hashiuchi; Hitoshi Watanabe; Kumi Kimura; Yu Oshima; Kohsuke Tsuchiya; Shin Murai; Chiaki Takahashi; Michihiro Matsumoto; Shigetaka Kitajima; Yasuhiko Yamamoto; Masao Honda; Shun-ichiro Asahara; Kim Ravnskjaer; Shin-ichi Horike; Shuichi Kaneko; Masato Kasuga; Hiroyasu Nakano; Kenichi Harada; Hiroshi Inoue
Source
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Aggravation of liver steatosis shifts the hepatocellular death mode from apoptosis to necroptosis in acute and chronic liver damage. Here the authors report that the transcription factor ATF3 regulates this shift through the induction of RIPK3, a regulator of necroptosis.