학술논문
Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations
Document Type
article
Author
Kensuke Nakagawara; Atsuho Morita; Ho Namkoong; Hideki Terai; Shotaro Chubachi; Takanori Asakura; Hiromu Tanaka; Fumimaro Ito; Emiko Matsuyama; Masanori Kaji; Ayaka Saito; Hatsuyo Takaoka; Masahiko Okada; Keeya Sunata; Mayuko Watase; Kazuma Yagi; Keiko Ohgino; Jun Miyata; Hirofumi Kamata; Ichiro Kawada; Keigo Kobayashi; Toshiyuki Hirano; Takashi Inoue; Junko Kagyo; Tetsuya Shiomi; Kengo Otsuka; Naoki Miyao; Toshio Odani; Rie Baba; Daisuke Arai; Ichiro Nakachi; Soichiro Ueda; Yohei Funatsu; Hidefumi Koh; Kota Ishioka; Saeko Takahashi; Morio Nakamura; Toshiro Sato; Naoki Hasegawa; Yuko Kitagawa; Takanori Kanai; Makoto Ishii; Koichi Fukunaga
Source
Vaccine: X, Vol 15, Iss , Pp 100381- (2023)
Subject
Language
English
ISSN
2590-1362
Abstract
We conducted a subgroup analysis of a study on the long-term effects of COVID-19 (long COVID) in Japan to assess the effect of vaccination on long COVID symptoms. We assessed the clinical course of 111 patients with long COVID at the time of vaccination. The follow-up period was one year from the onset of COVID-19 or until the administration of the third vaccine dose. Of the 111 patients, 15 (13.5%) reported improvement, four (3.6%) reported deterioration, and 92 (82.9%) reported no change in their long COVID symptoms after vaccination. The most common long COVID symptoms before vaccination were alopecia, dyspnea, muscle weakness, fatigue, and headache among participants whose symptoms improved. Reduced dyspnea and alopecia were the most frequently reported improvements in symptoms after vaccination. Some symptoms persisted, including sleep disturbance, myalgia, and hypersensitivity. Vaccination did not appear to have a clinically important effect on patients with long COVID symptoms.