학술논문
Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance
Document Type
article
Author
Mark A. Tye; N. Connor Payne; Catrine Johansson; Kritika Singh; Sofia A. Santos; Lọla Fagbami; Akansha Pant; Kayla Sylvester; Madeline R. Luth; Sofia Marques; Malcolm Whitman; Maria M. Mota; Elizabeth A. Winzeler; Amanda K. Lukens; Emily R. Derbyshire; Udo Oppermann; Dyann F. Wirth; Ralph Mazitschek
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The development of antimalarials against the human liver and asexual blood stages is one of the top public health challenges. Here, the authors report a single-step biochemical assay for the characterization of prolyl-tRNA synthetase inhibitors, and develop high-affinity inhibitors for the enzyme, including elusive triple-site ligands.