학술논문
Preclinical development of a miR-132 inhibitor for heart failure treatment
Document Type
article
Author
Ariana Foinquinos; Sandor Batkai; Celina Genschel; Janika Viereck; Steffen Rump; Mariann Gyöngyösi; Denise Traxler; Martin Riesenhuber; Andreas Spannbauer; Dominika Lukovic; Natalie Weber; Katrin Zlabinger; Ena Hašimbegović; Johannes Winkler; Jan Fiedler; Seema Dangwal; Martin Fischer; Jeanne de la Roche; Daniel Wojciechowski; Theresia Kraft; Rita Garamvölgyi; Sonja Neitzel; Shambhabi Chatterjee; Xiaoke Yin; Christian Bär; Manuel Mayr; Ke Xiao; Thomas Thum
Source
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine models of heart failure.