학술논문
Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
Document Type
article
Author
Lucy I. Crouch; Marcelo V. Liberato; Paulina A. Urbanowicz; Arnaud Baslé; Christopher A. Lamb; Christopher J. Stewart; Katie Cooke; Mary Doona; Stephanie Needham; Richard R. Brady; Janet E. Berrington; Katarina Madunic; Manfred Wuhrer; Peter Chater; Jeffery P. Pearson; Robert Glowacki; Eric C. Martens; Fuming Zhang; Robert J. Linhardt; Daniel I. R. Spencer; David N. Bolam
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Epithelial cells that line the gut secrete complex glycoproteins that form a mucus layer to protect the gut wall from enteric pathogens. Here, the authors provide a comprehensive characterisation of endo-acting glycoside hydrolases expressed by mucin-degrading members of the microbiome that are able to cleave the O-glycan chains of a range of different animal and human mucins.