학술논문
Deciphering the state of immune silence in fatal COVID-19 patients
Document Type
article
Author
Pierre Bost; Francesco De Sanctis; Stefania Canè; Stefano Ugel; Katia Donadello; Monica Castellucci; David Eyal; Alessandra Fiore; Cristina Anselmi; Roza Maria Barouni; Rosalinda Trovato; Simone Caligola; Alessia Lamolinara; Manuela Iezzi; Federica Facciotti; Annarita Mazzariol; Davide Gibellini; Pasquale De Nardo; Evelina Tacconelli; Leonardo Gottin; Enrico Polati; Benno Schwikowski; Ido Amit; Vincenzo Bronte
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Integrated studies of matched tissue sites and cell types in COVID-19 patients are important to define the immune mechanisms of pathology. Here, the authors describe an immune signature in fatal COVID-19 patients harmonizing single-cell RNA sequencing of blood and matched BAL cells with deep clinical, immunological and functional data.