학술논문
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
Document Type
article
Author
Pei Y. Liu; Andrew E. Tee; Giorgio Milazzo; Katherine M. Hannan; Jesper Maag; Sujanna Mondal; Bernard Atmadibrata; Nenad Bartonicek; Hui Peng; Nicholas Ho; Chelsea Mayoh; Roberto Ciaccio; Yuting Sun; Michelle J. Henderson; Jixuan Gao; Celine Everaert; Amy J. Hulme; Matthew Wong; Qing Lan; Belamy B. Cheung; Leming Shi; Jenny Y. Wang; Thorsten Simon; Matthias Fischer; Xu D. Zhang; Glenn M. Marshall; Murray D. Norris; Michelle Haber; Jo Vandesompele; Jinyan Li; Pieter Mestdagh; Ross D. Hannan; Marcel E. Dinger; Giovanni Perini; Tao Liu
Source
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
MYCN amplification is common in neuroblastomas. Here, the authors identify a long noncoding RNA, lncNB1 in these cancers and show that it promotes tumorigenesis by binding to ribosomal protein, RPL35 to enhance E2F1 and DEPDC1B protein synthesis, which phosphorylates ERK to stabilise N-Myc.