학술논문
Genomic characterization of rare molecular subclasses of hepatocellular carcinoma
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Jeffrey Damrauer, Markia Smith et al. used existing datasets from cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) to characterize two subsets of HCC distinct from prototypical HCC tumors, based on comprehensive analysis of molecular data. The two classes differed from HCC by their copy number, gene expression and mutational signature and exhibited worse progression free survival, highlighting the need to identify class-specific biomarkers and develop targeted therapies for these forms of cancer.