학술논문
USP1-trapping lesions as a source of DNA replication stress and genomic instability
Document Type
article
Author
Source
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Here the authors provide mechanistic insights into how auto-cleavage of the USP1 deubiquitinase regulates DNA replication and genome stability. Implications for the targeting of USP1 activity via protein-DNA trapping in cancer therapy are discussed.