학술논문
Desmopressin testing in von Willebrand disease: Lowering the burden
Document Type
article
Author
Source
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 6, Pp n/a-n/a (2022)
Subject
Language
English
ISSN
2475-0379
Abstract
Abstract Background Individuals with von Willebrand disease (VWD) require desmopressin testing because of interindividual response differences. However, testing is burdensome, while not all patients may need extensive testing. Objectives To provide von Willebrand factor (VWF) cutoffs that predict desmopressin nonresponse and thereby identify individuals who do not need extensive testing in a retrospective cohort. We validated these cutoffs in a prospective cohort. Patients and Methods We included 376 patients (Type 1 VWD with VWF activity [VWF:Act]