학술논문
A circular RNA generated from an intron of the insulin gene controls insulin secretion
Document Type
article
Author
Lisa Stoll; Adriana Rodríguez-Trejo; Claudiane Guay; Flora Brozzi; Mustafa Bilal Bayazit; Sonia Gattesco; Véronique Menoud; Jonathan Sobel; Ana Claudia Marques; Morten Trillingsgaard Venø; Jonathan Lou S. Esguerra; Mohammad Barghouth; Mara Suleiman; Lorella Marselli; Jørgen Kjems; Lena Eliasson; Erik Renström; Karim Bouzakri; Michel Pinget; Piero Marchetti; Romano Regazzi
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Circular RNAs contribute to the regulation of β-cell specific functions. Here the authors show that a circular RNA derived from one of the introns of the insulin gene is necessary for optimal insulin secretion from pancreatic islets and that its level is reduced in the islets of diabetic subjects.