학술논문
Association of Cytogenetics Aberrations and IGHV Mutations with Outcome in Chronic Lymphocytic Leukemia Patients in a Real-World Clinical Setting
Document Type
article
Author
Carolina Muñoz-Novas; Isabel González-Gascón-y-Marín; Iñigo Figueroa; Laura Sánchez-Paz; Claudia Pérez-Carretero; Miguel Quijada-Álamo; Ana-Eugenia Rodríguez-Vicente; María-Stefania Infante; María-Ángeles Foncillas; Elena Landete; Juan Churruca; Karen Marín; Victoria Ramos; Alejandro Sánchez Salto; José-Ángel Hernández-Rivas
Source
Global Medical Genetics, Vol 11, Iss 01, Pp 059-068 (2024)
Subject
Language
English
ISSN
2699-9404
Abstract
Immunoglobulin heavy chain variable (IGHV) region mutations, TP53 mutation, fluorescence in situ hybridization (FISH), and cytogenetic analysis are the most important prognostic biomarkers used in chronic lymphocytic leukemia (CLL) patients in our daily practice. In real-life environment, there are scarce studies that analyze the correlation of these factors with outcome, mainly referred to time to first treatment (TTFT) and overall survival (OS). This study aimed to typify IGHV mutation status, family usage, FISH aberrations, and complex karyotype (CK) and to analyze the prognostic impact in TTFT and OS in retrospective study of 375 CLL patients from a Spanish cohort. We found unmutated CLL (U-CLL) was associated with more aggressive disease, shorter TTFT (48 vs. 133 months, p