학술논문
Cangrelor ameliorates CLP-induced pulmonary injury in sepsis by inhibiting GPR17
Document Type
article
Author
Source
European Journal of Medical Research, Vol 26, Iss 1, Pp 1-7 (2021)
Subject
Language
English
ISSN
2047-783X
46813292
46813292
Abstract
Abstract Background Sepsis is a common complication of severe wound injury and infection, with a very high mortality rate. The P2Y12 receptor inhibitor, cangrelor, is an antagonist anti-platelet drug. Methods In our study, we investigated the protective mechanisms of cangrelor in CLP-induced pulmonary injury in sepsis, using C57BL/6 mouse models. Results TdT-mediated dUTP Nick-End Labeling (TUNEL) and Masson staining showed that apoptosis and fibrosis in lungs were alleviated by cangrelor treatment. Cangrelor significantly promoted surface expression of CD40L on platelets and inhibited CLP-induced neutrophils in Bronchoalveolar lavage fluid (BALF) (p