학술논문
Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
Document Type
article
Author
Philip Webster; Joanna C. Dawes; Hamlata Dewchand; Katalin Takacs; Barbara Iadarola; Bruce J. Bolt; Juan J. Caceres; Jakub Kaczor; Gopuraja Dharmalingam; Marian Dore; Laurence Game; Thomas Adejumo; James Elliott; Kikkeri Naresh; Mohammad Karimi; Katerina Rekopoulou; Ge Tan; Alberto Paccanaro; Anthony G. Uren
Source
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Evidence implicating cancer drivers can be sparse when limited to clonal events. Here, the authors present a retrovirus driven in vivo lymphomagenesis time course including hundreds of thousands of subclonal mutations and demonstrate the utility of these in mapping the selective forces affecting cancer gene loci, including negatively selected mutations.