학술논문
Potential candidates for liver resection in liver-confined advanced HCC: a Chinese multicenter observational study
Document Type
article
Author
Tingting Bai; Enxin Wang; Shoujie Zhao; Dandan Han; Yan Zhao; Hui Chen; Jun Zhu; Tenghui Han; Yang Bai; Yanju Lou; Yongchao Zhang; Man Yang; Luo Zuo; Jiahao Fan; Xing Chen; Jia Jia; Wenbin Wu; Weirong Ren; Yejing Zhu; Shouzheng Ma; Fenghua Xu; Yuxin Tang; Xilin Du; Junlong Zhao; Jing Li; Xingshun Qi; Ying Han; Dongfeng Chen; Lei Liu
Source
Frontiers in Oncology, Vol 13 (2023)
Subject
Language
English
ISSN
2234-943X
Abstract
BackgroundAdvanced hepatocellular carcinoma (HCC) is characterized as symptomatic tumors [performance status (PS) score of 1-2], vascular invasion and extrahepatic spread, but patients with PS1 alone may be eliminated from this stage. Although liver resection is used for liver-confined HCC, its role in patients with PS1 alone remains controversial. Therefore, we aimed to explore its application in such patients and identify potential candidates.MethodsEligible liver-confined HCC patients undergoing liver resection were retrospectively screened in 15 Chinese tertiary hospitals, with limited tumor burden, liver function and PS scores. Cox-regression survival analysis was used to investigate the prognostic factors and develop a risk-scoring system, according to which patients were substratified using fitting curves and the predictive values of PS were explored in each stratification.ResultsFrom January 2010 to October 2021, 1535 consecutive patients were selected. In the whole cohort, PS, AFP, tumor size and albumin were correlated with survival (adjusted P