학술논문
A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes
Document Type
article
Author
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Human leukocyte antigen (HLA) genes contribute to risk of many complex traits, yet understanding inter-ethnic heterogeneity is computationally challenging. Here, the authors develop DEEP*HLA for imputation of HLA genotypes and show its ability to disentangle HLA variant risk effects in diverse populations.