학술논문
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity
Document Type
article
Author
Miriam Rosás-Umbert; Jesper D. Gunst; Marie H. Pahus; Rikke Olesen; Mariane Schleimann; Paul W. Denton; Victor Ramos; Adam Ward; Natalie N. Kinloch; Dennis C. Copertino; Tuixent Escribà; Anuska Llano; Zabrina L. Brumme; R. Brad Jones; Beatriz Mothe; Christian Brander; Julie Fox; Michel C. Nussenzweig; Sarah Fidler; Marina Caskey; Martin Tolstrup; Ole S. Søgaard
Source
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Broadly neutralising anti-HIV-1 antibody (bNAb) administration in nonhuman primates has been shown to stimulate adaptive T cell-specific immunity, with infection prevention observed. In this work, the authors longitudinally analyse HIV-1 specific cellular immunity in HIV-1- infected individuals starting ART with or without adjunctive bNAb treatment.