학술논문
A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
Document Type
article
Author
Jacqui A. McGovern; Nathalie Bock; Abbas Shafiee; Laure C. Martine; Ferdinand Wagner; Jeremy G. Baldwin; Marietta Landgraf; Christoph A. Lahr; Christoph Meinert; Elizabeth D. Williams; Pamela M. Pollock; Jim Denham; Pamela J. Russell; Gail P. Risbridger; Judith A. Clements; Daniela Loessner; Boris M. Holzapfel; Dietmar W. Hutmacher
Source
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
McGovern et al. establish an orthotopic, humanized prostate cancer model to study bone metastasis. The authors demonstrate that a humanized tumor microenvironment (TME) influences the metastatic spread of cancer cells to tissue-engineered bone, highlighting the importance of the TME in prostate cancer metastasis to bone.